This study explores the determinants of the quality of life (QOL) of married women in India, focusing on regional and socio-economic factors using data from the National Family Health Survey (NFHS-5). About 5,239 married women in India are considered for the study. A Quality of Life (QOL) index has been generated from related household characteristics. Most of the women face average quality of life. Women from the South and North East regions report higher QOL while the Central regions show the lowest QOL. Rural women experience 0.054-point lower QOL than urban women. Similarly, higher education and better occupational status positively influence QOL of women. Women whose husbands have high and medium education or high-level occupations experience better QOL. Women who are heads of households report higher QOL. Illness and husband’s alcoholism have minimal impact. Finally, nuclear families report better QOL than joint families. Women’s quality of life in India varies by region and education. Policies should focus on education, economic security, and reducing regional inequalities to empower women.