Depression among adolescents and young adults is a significant public health concern with far-reaching implications for individuals, families, and societies. The frequency and demographic  trends of depression in adolescents and young adults, highlighting the complex interactions between biological, psychological, and social elements that influence the illness’s development. Since depression is a diverse range of illnesses, it is likely to have subgroups with a stronger hereditary component. Similar to other neuropsychiatric conditions including Huntington’s disease, schizophrenia, and Alzheimer’s disease, depression is linked to a worse prognosis in the long run and a greater genetic loading at the early age of start. It highlights the importance of addressing comorbidities such as substance abuse, self-harm, and suicidality in treatment planning. Depressed adolescents and young adults are also more likely to get bipolar disorder. This article discusses depressions that initially manifest in youth and early adulthood. The paper stresses the need of tackling depression in adolescents and young adults through a holistic and multidisciplinary strategy. In order to create efficient preventative and intervention plans that support mental health and wellbeing in this susceptible group, it is necessary for researchers, and other community members to collaborate more closely.