Low birth weight (LBW) is a standout amongst the most vital pointer of infant’s helplessness to the danger of youth disease and odds of survivals of the newborn children. It is additionally a main worldwide reason for youth dismalness and mortality. The aim of the study was to identify the risk factors associated with LBW in Khulna, Bangladesh. A cross sectional study was conducted from 13 August to 17 October, 2018. The review was directed with the premise of the registered book of Surjer Hashi clinic (CHC) (2017-2018) at Nirala in Khulna. An aggregate of 1708 children’s information was accessible at the registered book. A total number of 187 samples were selected from 1708 children by simple random sampling. Necessary information was collected using a standard questionnaire. Data was gathered from the enlisted book of the clinic and guardians of the children. The association between the independent variables and outcome variable was evaluated through Chi-square test. Multiple binary logistic regressions were used to identify the significant factors. This study revealed that the prevalence of LBW children was 31%. It was found that regular checkup (AOR=0.22, 95% CI (0.07, 0.72), p<0.05), daily amount of taking food (AOR=0.189, 95% CI (0.05, 0.79), p<0.05) and medicines during pregnancy (AOR=0.060, 95% CI (0.02, 0.24), p<0.05) were associated with low birth weight. Enhancing the mother’s mindfulness and practice for a pregnancy that results in a healthy baby weighting at least five and a half pounds who has no birth defects should be accentuated to invert LBW related issue. With the fitting administration of low birth weight babies, an expansive number of neonate passing’s can be decreased.