Down syndrome is the most common chromosomal disorder which involves trisomy for chromosome 21. This disorder is usually diagnosed at the time of birth or shortly thereafter by its phenotypic features in which hypotonia is one of the common abnormality. Individuals with Down syndrome have learning disability, mental retardation, brachycephalic head and eyes with epicanthic folds. The objectives of the study were to provide the height, weight and body mass index of males with Down syndrome. The cross-sectional data on 25 Down syndrome subjects and 25 healthy controls, ranging in age from 18 to 40 years were collected during 2014-2015 from September 2014 to March 2015. The controls were age and sex matched individuals with no health complications. Anthropometric measurements of height and weight were taken using standard methods and BMI was also calculated from these two measurements. There were significant differences in height, weight and BMI of males with Down syndrome and controls. Out of the total sample, 18 (72%) individuals with Down syndrome were obese, whereas 7 (28%) of them were normal. Similarly, among controls, 5(20%) were obese and 20 (80%) were normal. Chi-Square value was calculated for individuals with Down syndrome and age and sex matched controls. The difference was statistically significant with p value 0.0002. The individuals with Down syndrome were shorter in height but heavier in weight and had higher values of BMI. There were statistically significant differences in the mean height, weight and BMI of males with Down syndrome than the controls.