This study was undertaken to determine whether exposure of raw tobacco causes respiratory diseases, lung function impairment and parenchymal changes among workers in cigarette industry. Total subjects studied (n=125), out of which 67 were Non exposed workers or control subjects and 58 were workers exposed to dried tobacco leaves in Cigarette and Beedi Industry of Varanasi-Mirzapur belt, Uttar Pradesh, India. The study included completion of a questionnaire (on pulmonary and respiratory problems, spirometry and measurement of peak expiratory flow rate. At the same time, Paired t-test was done to determine the significant difference between cigarette workers and control subjects. Cigarette workers had significantly lower percentage of predicted values of FVC, FEV1 and FEV1% than control subjects (p <0.001). This study indicates that Cigarette workers may have respiratory and pulmonary disorders related to exposure to tobacco dust in their work environment.