Cancer is one of the leading causes of adult deaths worldwide. The Eastern Uttar Pradesh region of India lies on the Indo-Gangetic plain and together with western Bihar is the most-denselypopulated area in the world. There is scarcity of data on epidemiological profile of cancer patients of this region. The objective of present study was to do an epidemiological survey in cancer hospital setup of this region. Data were collected from the Hospital Cancer Registry of Hanumaan Prasad Poddar Cancer Hospital and Research Institute, Gorakhpur. Results were expressed in the form of percentages and proportions. We have found that 750 cancer cases were registered during the study period (November 2018 to January 2019). Out of which, 404 cases were proven to having cancer of different sites. Oral cancer is on first position followed by bladder, cervix, and breast cancer respectively. As with the previous studies chewing tobacco is primary cause of most oral cancers. Additional research is needed to access the impact of diverse locality, food habit, religious practice, and lifestyle, on growth and prevention of different cancers