Addictive behaviors exert an enormous cost on society. Cigarette smoking, like other substances of abuse is a public health problem associated with considerable morbidity, mortality, personal and public cost. In the present study, we have attempted to investigate possible links between the dopamine receptor gene DRD1 and smoking behavior in smokers inhabiting the North West Indian region. A total of 361 subjects (173 smokers with a mean age 35.37±14.29 years and 188 healthy age/ethnicity matched non-smokers with a mean age of 35.79±13.37 years) participated in the study. The degree of nicotine dependence was ascertained by commonly used measure: The Fagerstrom Test for Nicotine Dependence (FTND). Measures such as cigarettes per day, smoking history, pack years smoked and age at initiation of smoking were also used as predictive measures of nicotine dependence. On categorization of smokers into low nicotine dependence (LND) and high nicotine dependence (HND), significantly high differences were seen between HND vs. LND for all the smoking related variables except age at initiation of smoking. However, our study could not find any significant associations between various smoking variables and DRD1 genotypes. Also, no significant differences were seen between smokers and non-smokers at both genotypic and allelic level.