The study of musculoskeletal variations has systematically improved overtime in the study of vertebrate anatomy and human biology. Primates possess features that are uniquely relevant compared to other vertebrates. One of such features is the ability of their prehensile hands to form handgrip manipulations. Grip actions however, differ among primates and this current study seeks to possibly suggest how the pollical palmer interosseous muscle (PPIM) plays a significant role in ensuring these grip morphological differences between humans and non-human primates.