Bipolar disorder (BPD) affects personal and social functioning and creates huge economic burden. This type of study is poorly documented in Bangladesh. This study was designed to determine the prevalence and investigate the associated factors of BPD among married adult males in Rajshahi city, Bangladesh. For collecting data for this household cross-sectional study, multistage stratified systematic sampling and a semi-structured questionnaire was used. Frequency distribution, chi-square test and binary logistic regression model were used to determine the prevalence, and investigate the associated factors of BPD respectively. The prevalence of BPD and probable BPD was found to be 1.1% and 5.1% respectively. After controlling the effect of other factors it was found that married adult males with no education (AOR=6.300, 95 % CI: 1.863-21.307; p<0.01), under nutrition (AOR=7.692, 95 % CI: 1.959-30.201; p<0.01), hard work (AOR=4.105, 95 % CI: 1.360-12.394; p<0.05), poor relationship with partner (AOR=0.097 95 % CI: 0.022-0.436; p<0.01), substance abuse (AOR=0.086, 95 % CI: 0.034-0.215; p<0.01), mental disease (AOR=0.258, 95 % CI: 0.068-0.984; p<0.05), blood-relative’s mental disease (AOR=0.069, 95 % CI: 0.017-0.278; p<0.01), stress/anxiety (AOR=0.166, 95 % CI: 0.048-0.571; p<0.01), suicidal thought/attempt (AOR=8.583, 95 % CI: 2.679-27.495; p<0.01), blood-relative’s suicide/suicidal attempt (AOR=0.093, 95 % CI: 0.030-0.285; p<0.01) and chronic disease (AOR=0.187, 95 % CI: 0.075-0.466; p<0.01) were more likely to get BPD than their counterparts. In this study, we determined risk factors of BPD among Bangladeshi married adult males all of which are modifiable. Health professionals may consider these factors while giving treatment.